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Published Resources

Key published manuscripts/references 

  1. Cockburn A et al. High throughput DNA sequencing to detect differences in subgingival plaque microbiome in elderly subjects with and without dementia. J of Experimental Genetics. Oct. 2012.
  2. Williams D et al. The role of the human oral microflora in ventilator-associated pneumonia. Annual Clin J of Dental Health. Dec. 2011
  3. Robinson P et al. A distributed national network for label-free rapid identification of emerging pathogens.
  4. Eckley B et al. Periodontal and microbiological status of patients undergoing orthodontic therapy. Hong Kong Dent J. Sept. 2012.
  5. Olson J et al. Use of 16s ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia. BMC Oral Health. November 2011.
  6. Editor. The human microbiome: me, myself, us. The Economist. August 18, 2012.
  7. Cairns S et al. Molecular analysis of microbial  communities in endotracheal tube biofilms. P LoS ONE. June 2011.
  8. Percival S et al. Biofilms in bacterial imbalances in chronic wounds: anti-Koch. International Wound Journal.
  9. Wilson A et al. Advanced endotracheal tube biofilm stage, not duration of intubation, is related to pneumonia. J Trauma and Acute Care Surgery. April 2012.
  10. Wilson A et al. Increases in endotrachela tube resistance are unpredictable relative to duration of intubation. Chest. 2009.
    See Below
  11. Thomas JG. Managing the complexity of a dynamic biofilm. J Am Dent Assoc. 2006.
  12. Pinciorli R et al.  Use of high Definition Computed Tomagraphy to Assess ETT luminal narrowing after MV. J  Anesthesiology (accepted) 2013
  13. Bretzw et al. Familial Oral Microbiology Imbalance  and Dental Caries  Occurrence in their Children (Submitted) 2013  


Increases in Endotracheal Tube Resistance Are Unpredictable Relative to Duration of Intubation

Background: Accumulated secretions after intubation can affect the resistance of an endotracheal tube (ETT). Our objective was to measure extubated patient tubes and size-matched controls to evaluate differences in resistance.

Methods: New ETT's with internal diameters of 7.0 through 8.5 mm, were tested as controls to establish the resistance of each size group as measured by pressure drop. Measurements were obtained using a mass flowmeter and pressure transducer. Pressure drop was measured at three flow rates. Sevety-one patient ETT's were evaluated after extubation by an identical method and compared with controls.

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Authors: Alison M. Wilson, MD; Dana M. Gray; and John G. Thomas, PhD.


Probiotics and your Sinus Health

Probiotic and your sinus healthSelected probiotics & prebiotics have received international attention, which is a reflection of the global expenditures and investment in new probiotics. 30% of the international population uses probiotics at an annual expenditure of $85.7 billion with a 15% growth rate. The UK, Asia Pacific and the US, in order, are the largest users and focused markets for new products. In 2008, there were 232 products, and 139 within the first six month of 2009. “Designer Probiotics” and “Preventative Probiotics” are recognized as the newest focus, in addition to Mechanism of Action.

In this book, we focus on the adjunctive Preventative and Therapeutic potential of a mixed probiotic capsule containing four individual organisms; each serving a unique function in either 1) replacing pathogenic sinusitis focused bacteria, or 2) enhancing the local sinus tract immunity.

Sinus health is a complex interaction of environmental, bacterial, fungal, and immunologic forces, always under stress of simple facts: age, underlying disease, geographic location, and month, but maintaining a health microbial microbiota, supplemented with pre- and probiotics is consistent with growing awareness of disease processes of sinusitis and methods of management.

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Author: John Thomas, PhD.

 

Pneumonia in the ICU

Pneumonia in the ICU

Managing Oral Pathogens for Prevention and Treatment

Ventilator-associated pneumonia is the most common infectious complication among patient in the intensive care unit (ICU), accounting for more than 47% of all infections. Critically ill patients who develop VAP are twice as likely to die compared to those who do not develop it. In addition, VAP can considerably increase healthcare costs, adding to $40,000 to a hospital admission.

For the last decade, it has become increasingly clear that oral care addresses the risk factors for VAP – bacterial colonization of the oropharyngeal area, colonization of dental plaque with respiratory pathogens, and a co-biofilm development in the endotracheal lumen.

The new book describes the growing evidence of the importance of oral cavity microbes in the development of VAP and outlines the development of a comprehensive oral care system – a schedule of tooth-brushing, suction, swabbing, rinsing with antiseptic and antiplaque agents, and debriding.

The ICU VAP Booklet has been certified by Medcom, Inc for Continuing Education Activity.

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Author: John Thomas, PhD.

 

Probiotics - The key to a Healthy Digestive and Immune SystemProbiotics

The key to a Healthy Digestive and Immune System

Your overall good health depends on a healthy functioning digestive system. The bacteria present in your digestive tract play a major role. Imbalances in the types of gut flora (friendly vs. harmful) can lead to digestive disturbances, which, if left unchecked, can lead to more serious health issues.

Researchers have observed that certain organism, primarily species of lactobacillus or bifidobacterium, have health promoting benefits.

In Probiotic: The Key to a Healthy Digestive and Immune System, you will discover that one such bacterium, Lactobacillus plantaram 299v (Lp299v), has been clinically proven to be not only beneficial to the digestive system, but also to one's overall health.

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Author: John Thomas, PhD.
 

Probiotics-Link-Between-Beneficial-Oral-BacProbiotics

The Link Between Beneficial Oral Bacteria and Total Health

It is estimated today that over 80% of all Americans suffer from gum disease and 35 million have a severe form of it. Conventional treatments for advanced gum (peridontal) disease can be very expensive and painful. While brushing, flossing, and regular visits to the dentist can certainly go a long way toward preventing gum disease, scientists have idenified powerful new tools to fight this "silent epidemic".

Mounting evidence reveals that peridontal disease can be the starting point for illnesses such as cardiovascular disease, diabetes, stroke, and respiratory ailments. New research suggests that probiotics, specifically Lactobacillus reuteri, may prevent - and even reverse - signs of gum disease.

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Author: John Thomas, PhD.